Selected Product:
| Ion Channels of Excitable Membranes (3rd Edition)
Hardcover
Edition: 3rd Casebound
Author: Bertil Hille
Publisher: Sinauer Associates
Release Date: 2001-07-01
ISBN-10: 0878933212
ISBN-13: 9780878933211
List Price: $101.95
Average Customer Rating:
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Summaries and Customer Reviews are supplied by Amazon.com
Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded Third Edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.
The bane of my spring semester
| Customer Rating:  | | Although this book is very thorough when it comes to 'ion channels of excitable membranes,' it's essentially a 1000-page literature review. That's fine if you're an expert in the field (i.e. college professor), but for an undergraduate, it contained an overwhelming amount of information, including calculus-based math. Sometimes, it was helpful to consult when my class notes were incomplete. Otherwise, reading the assigned chapters in this book proved a waste of time. |
Excellent and useful text.
| Customer Rating: | | This text is an encyclopedia of information from kinetics to structure to interactions. It's got a reserved space on my academic bookshelf. |
Destined to become an Oprah Book Club selection
| Customer Rating: | Some books have opening sentences that grab you in an instant. "Call me Ishmael." "It was the best of times, it was the worst of times." And now, Hille joins the list of authors to reach out and grab us, with the awe-inspiring "Ion channels are macromolecular pores in cell membranes."
Even after my fifth reading, that line still gives me the shivers.
But it takes more than a brilliant opening to make a great book, and Hille delivers. From a distinctly jaunty derivation of the Nernst equation to the page-turning thrills of non-stationary fluctuation analysis, the book is hard to put down. It does bog down a little in Chapter 10, "Elementary Properties of Ions in Solution"--after all, is there anyone who isn't already aware of the fundamentals of electrodiffusion? But this is really a minor trifle in an otherwise masterful work.
It's just a matter of time before Oprah gives this book a nod; buy it now and avoid the rush! |
Keeps getting better with each Edition
| Customer Rating: | | This book is a must-have for anyone working with excitable cells, be they experimentalists or modelers. It's a great reference book; everything is clearly indexed and almost compulsively cited. I've been using this book since its first edition, and it just keeps getting better each time. |
Rara avis
| Customer Rating: | | This classic deserves all the praise it gets. It is an excellent introduction to the molecular biology of channels, told with an eye to history as well as science. |
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